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Turkish Society of Cardiology
Young Cardiologists
President
Dr. Muzaffer Değertekin
Coordinator for the
Board of Directors
Dr. Ertuğrul Okuyan
Coordinator for the
Board of Directors
Dr. Can Yücel Karabay
Members
Dr. Adem Aktan
Dr. Gülşah Aktüre
Dr. Bayram Arslan
Dr. İnanç Artaç
Dr. Ahmet Oğuz Aslan
Dr. Görkem Ayhan
Dr. Ahmet Anıl Başkurt
Dr. Özkan Bekler
Dr. Oğuzhan Birdal
Dr. Yusuf Bozkurt Şahin
Dr. Serkan Bulgurluoğlu
Dr. Ümit Bulut
Dr. Veysi Can
Dr. Mustafa Candemir
Dr. Murat Çap
Dr. Göksel Çinier
Dr. Ali Çoner
Dr. Yusuf Demir
Dr. Ömer Furkan Demir
Dr. Murat Demirci
Dr. Ayşe İrem Demirtola Mammadli
Dr. Süleyman Çağan Efe
Dr. Mehmet Akif Erdöl
Dr. Kubilay Erselcan
Dr. Kerim Esenboğa
Dr. Duygu Genç
Dr. Kemal Göçer
Dr. Elif Güçlü
Dr. Arda Güler
Dr. Duygu İnan
Dr. Hasan Burak İşleyen
Dr. Muzaffer Kahyaoğlu
Dr. Sedat Kalkan
Dr. Yücel Kanal
Dr. Özkan Karaca
Dr. Ahmet Karaduman
Dr. Mustafa Karanfil
Dr. Ayhan Kol
Dr. Fatma Köksal
Dr. Mevlüt Serdar Kuyumcu
Dr. Yunus Emre Özbebek
Dr. Ahmet Özderya
Dr. Yasin Özen
Dr. Ayşenur Özkaya İbiş
Dr. Çağlar Özmen
Dr. Selvi Öztaş
Dr. Hasan Sarı
Dr. Serkan Sivri
Dr. Ali Uğur Soysal
Dr. Hüseyin Tezcan
Dr. Nazlı Turan
Dr. Berat Uğuz
Dr. Örsan Deniz Urgun
Dr. İdris Yakut
Dr. Mustafa Yenerçağ
Dr. Mehmet Fatih Yılmaz
Dr. Yakup Yiğit
Dr. Mehmet Murat Yiğitbaşı
Bulletin Editors
Dr. Muzaffer Değertekin
Dr. Can Yücel Karabay
Dr. Muzaffer Kahyaoğlu
Contributors
Dr. Ahmet Caner Canpolat
Dr. Aysu Oktay
Dr. Hadi Verdiyev
Dr. Kemal Göçer
Dr. Mehmet Altunova
Dr. Mehmet Murat Yiğitbaşı
Dr. Merve Kapçık
Dr. Muhammed Ali Söyler
Dr. Muhammet Ali Ekiz
Dr. Mustafa Yenerçağ
Dr. Mustafa Yılmaz
Dr. Özkan Karaca
Dr. Ramazan Furkan Demirkıran
Dr. Seda Kurat Güldoğmuş
Dr. Sefa Sarı
Dr. Selim Süleyman Sert
Dr. Serkan Bulguroğlu
Dr. Ülkü Nur Koç
Dr. Yücel Kanal
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Valve Under-Expansion and Clinical Outcomes with ACURATE neo2: Findings from the ACURATE IDE TrialTürk Kardiyoloji Derneği Genç Kardiyologlar Bülteni - Valve Under-Expansion and Clinical Outcomes with ACURATE neo2: Findings from the ACURATE IDE Trial (Dr. Muhammed Ali Söyler)Prepared by: Dr. Muhammed Ali Söyler
Name of Study: Valve Under-Expansion and Clinical Outcomes with ACURATE neo2: Findings from the ACURATE IDE Trial
Presented at: EuroPCR 2025
Link: https://www.jacc.org/doi/10.1016/j.jacc.2025.05.011
Introduction:
ACURATE neo2 is a new generation self expanding transcatheter aortic valve. In the ACURATE neo2 valve vs other balloon-expandable (SAPIEN3/ULTRA) and self expanding (Evolut R/PRO/PRO+/FX) valves trial, ACURATE neo2 did not meet non-inferiority criteria when compared to the other aortic valves.
Objective:
To evaluate impact of ACURATE neo2 valve under expansion and clinical outcomes.
Methods:
Post hoc analysis of patients who are implanted ACURATE neo2 valves, in some patients there was angulated commissure posts which indicates valve under expansion. In the trial, 752 patient were implanted ACURATE neo2 valves. All these patient were evaluated with angiogram by indepedent core laboratory. Main aim in these study to evaluate association between valve expansion and clinical outcomes.
Results:
In this trial, 624 patient who were implanted with ACURATE neo2 were available for angiogram.135 patient (21.6%) had under expanded valves. Independent cause of under expansion of valve is associated with greater aortic valve leaflet and annulus calcification. There was no relation with under expansion of valves in procedural techniques such as frequency of predilation (100% in both groups) and postdilation (26.7% in under expanded group and 25.2% in expanded group) and balloon sizing. As a result, under expanded valves was associated with a higher 1 year rate of death, stroke, or rehospitalization (under expanded 18.7%, expanded 11.8%).
Conclusions:
These trial shows us under expanded ACURATE neo2 valves has higher rate of 1 year death, stroke and hospitalization. This under-expansion is more likely to occur in patient with greater aortic leaflet and calcific aortic annulus.
Commentary:
This study clearly demonstrates that in TAVI procedures, not only the appropriate valve selection but also optimal positioning and full expansion of the valve are critical determinants of clinical outcomes. These findings important for analyses in guiding future device design and development.
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