Türk Kardiyoloji Derneği Genç Kardiyologlar Bülteni - Evening dosing of blood pressure medication not better than morning dosing: TIME trial (Dr. İbrahim Halil Özdemir)

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Turkish Society of Cardiology Young Cardiologists Bulletin Year: 5 Number: 6 / 2022

Turkish Society of Cardiology
Young Cardiologists
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Dr. Muzaffer Değertekin

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Dr. Ertuğrul Okuyan

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Dr. Can Yücel Karabay

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Dr. Gülşah Aktüre
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Dr. Mehmet Fatih Yılmaz
Dr. Yakup Yiğit
Dr. Mehmet Murat Yiğitbaşı

Bulletin Editors
Dr. Muzaffer Değertekin
Dr. Bülent Mutlu
Dr. Süleyman Çağan Efe
Dr. Göksel Çinier
Dr. Duygu İnan
Dr. Sedat Kalkan

Contributors
Dr. Onur Akhan
Dr. Fatih Aksoy
Dr. Derya Baykiz
Dr. İlyas Çetin
Dr. Uğur Ozan Demirhan
Dr. Elif Ayduk Gövdeli
Dr. Mustafa Ferhat Keten
Dr. Bengisu Keskin Meriç
Dr. İbrahim Halil Özdemir
Dr. Mehmet Arslan
Dr. Hüseyin Durak
Dr. Levent Pay

Evening dosing of blood pressure medication not better than morning dosing: TIME trialTürk Kardiyoloji Derneği Genç Kardiyologlar Bülteni - Evening dosing of blood pressure medication not better than morning dosing: TIME trial (Dr. İbrahim Halil Özdemir)

Reviewer: Dr. İbrahim Halil Özdemir

Name of the Study: Evening dosing of blood pressure medication not better than morning dosing: TIME trial

Published Congress: ESC 2022

Link : https://www.escardio.org/The-ESC/Press-Office/Press-releases/Evening-dosing-of-blood-pressure-medication-not-better-than-morning-dosing

Background:

High blood pressure is an important cause of mortality and morbidity worldwide. Recent studies have shown that night-time blood pressure affects cardiovascular outcomes more than morning time blood pressure, and antihypertensive medication taken in the evening provides a greater reduction in blood pressure. However, the best treatment option in this regard is still unknown.

Objective:

The aim of this study was to investigate whether the evening dose of antihypertensive drugs improves major cardiovascular outcomes compared to the morning dose.

Methods:

Patients with a valid e-mail address and taking at least one antihypertensive drug were included in the study. Participants were randomized 1:1 according to their morning or evening antihypertensive medication after registering on the TIME website (http://www.timestudy.co.uk). The primary endpoint of the study was cardiovascular mortality and morbidity.

Results:

Of a total of 21,104 patients, 10,503 were randomized to the evening dose and 10,601 to the morning dose. The primary endpoint occurred in 362 (3.4%) (0.69 events 100 patients/year) participants in the evening medication group and 390 (3.7%) (0.72 events 100 patients/year) participants in the morning medication group [hazard ratio (HR) 0.95, 95% confidence interval (CI) 0.83–1.10; p=0.53].

Conclusion:

No superiority of evening dose of antihypertensive drug over morning dose was demonstrated.

Interpretations:

The TIME study showed that taking the antihypertensive drug in the evening or in the morning had no effect on cardiovascular mortality and morbidity. People with high blood pressure should take their antihypertensive treatment regularly and at the most convenient time of the day.