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Turkish Society of Cardiology
Young Cardiologists
President
Dr. Muzaffer Değertekin
Coordinator for the
Board of Directors
Dr. Ertuğrul Okuyan
Coordinator for the
Board of Directors
Dr. Can Yücel Karabay
Members
Dr. Adem Aktan
Dr. Gülşah Aktüre
Dr. Bayram Arslan
Dr. İnanç Artaç
Dr. Ahmet Oğuz Aslan
Dr. Görkem Ayhan
Dr. Ahmet Anıl Başkurt
Dr. Özkan Bekler
Dr. Oğuzhan Birdal
Dr. Yusuf Bozkurt Şahin
Dr. Serkan Bulgurluoğlu
Dr. Ümit Bulut
Dr. Veysi Can
Dr. Mustafa Candemir
Dr. Murat Çap
Dr. Göksel Çinier
Dr. Ali Çoner
Dr. Yusuf Demir
Dr. Ömer Furkan Demir
Dr. Murat Demirci
Dr. Ayşe İrem Demirtola Mammadli
Dr. Süleyman Çağan Efe
Dr. Mehmet Akif Erdöl
Dr. Kubilay Erselcan
Dr. Kerim Esenboğa
Dr. Duygu Genç
Dr. Kemal Göçer
Dr. Elif Güçlü
Dr. Arda Güler
Dr. Duygu İnan
Dr. Hasan Burak İşleyen
Dr. Muzaffer Kahyaoğlu
Dr. Sedat Kalkan
Dr. Yücel Kanal
Dr. Özkan Karaca
Dr. Ahmet Karaduman
Dr. Mustafa Karanfil
Dr. Ayhan Kol
Dr. Fatma Köksal
Dr. Mevlüt Serdar Kuyumcu
Dr. Yunus Emre Özbebek
Dr. Ahmet Özderya
Dr. Yasin Özen
Dr. Ayşenur Özkaya İbiş
Dr. Çağlar Özmen
Dr. Selvi Öztaş
Dr. Hasan Sarı
Dr. Serkan Sivri
Dr. Ali Uğur Soysal
Dr. Hüseyin Tezcan
Dr. Nazlı Turan
Dr. Berat Uğuz
Dr. Örsan Deniz Urgun
Dr. İdris Yakut
Dr. Mustafa Yenerçağ
Dr. Mehmet Fatih Yılmaz
Dr. Yakup Yiğit
Dr. Mehmet Murat Yiğitbaşı
Bulletin Editors
Dr. Muzaffer Değertekin
Dr. Can Yücel Karabay
Dr. Muzaffer Kahyaoğlu
Contributors
Dr. Ahmet Caner Canpolat
Dr. Aysu Oktay
Dr. Hadi Verdiyev
Dr. Kemal Göçer
Dr. Mehmet Altunova
Dr. Mehmet Murat Yiğitbaşı
Dr. Merve Kapçık
Dr. Muhammed Ali Söyler
Dr. Muhammet Ali Ekiz
Dr. Mustafa Yenerçağ
Dr. Mustafa Yılmaz
Dr. Özkan Karaca
Dr. Ramazan Furkan Demirkıran
Dr. Seda Kurat Güldoğmuş
Dr. Sefa Sarı
Dr. Selim Süleyman Sert
Dr. Serkan Bulguroğlu
Dr. Ülkü Nur Koç
Dr. Yücel Kanal
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ICARE-OFDI: Comparison of IVL vs RA for Calcified Coronary Lesions – OFDI EvaluationTürk Kardiyoloji Derneði Genç Kardiyologlar Bülteni - ICARE-OFDI: Comparison of IVL vs RA for Calcified Coronary Lesions – OFDI Evaluation (Dr. Merve Kapçık)Prepared by: Dr. Merve Kapçık
Study Title: ICARE-OFDI: Comparison of IVL vs RA for Calcified Coronary Lesions – OFDI Evaluation
Presented at: EuroPCR 2025
Link: pcronline.com
Introduction:
Calcified coronary lesions are common and can impair stenting outcomes. ICARE directly compares intravascular lithotripsy (IVL) and rotational atherectomy (RA) for plaque modification prior to stent placement.
Objective:
To assess whether IVL is non-inferior to RA regarding minimal stent area (MSA) and compare safety profiles.
Methods:
- Design: Prospective, multicenter, randomized non-inferiority trial
- Participants: 202 screened, 170 randomized (RA: 86, IVL: 83)
- Imaging: Optical Frequency Domain Imaging (OFDI)
- Primary endpoints: Acute MSA (efficacy), 30-day MACE (safety)
Results:
- MSA: RA = 5.5 mm²; IVL = 5.8 mm² (non-inferior, p<0.05)
- MSA <4.5 mm²: Similar (RA: 21%, IVL: 22%)
- Malapposition higher in RA (80% vs 61%, p=0.006)
- IVL had lower fluoroscopy time and contrast use
- Periprocedural MI: more frequent in RA (5.8% vs 0%, p=0.06)
- 30-day MACE: no significant difference; no early deaths or stent thrombosis
Conclusion:
IVL is non-inferior to RA in terms of efficacy and comparable in safety. It offers procedural advantages with less malapposition and resource use.
Comment:
IVL emerges as a safer, less invasive alternative to RA for calcified lesions, supporting broader clinical use pending long-term data.
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